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MCP Server MCP

io.github.cyanheads/ensembl-mcp-server

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Look up genes, sequences, variants, homologs, and cross-database xrefs from Ensembl REST.

Homepage Verified source GitHub

Install

npx -y @cyanheads/[email protected]

Configuration Example

{
  "remotes": [
    {
      "type": "streamable-http",
      "url": "https://ensembl.caseyjhand.com/mcp"
    }
  ],
  "packages": [
    {
      "registryType": "npm",
      "registryBaseUrl": "https://registry.npmjs.org",
      "identifier": "@cyanheads/ensembl-mcp-server",
      "version": "0.4.3",
      "runtimeHint": "bun",
      "transport": {
        "type": "stdio"
      },
      "packageArguments": [
        {
          "value": "run",
          "type": "positional"
        },
        {
          "value": "start:stdio",
          "type": "positional"
        }
      ],
      "environmentVariables": [
        {
          "description": "Ensembl REST API base URL. Override to use GRCh37 endpoint or a local mirror.",
          "format": "string",
          "default": "https://rest.ensembl.org",
          "name": "ENSEMBL_BASE_URL"
        },
        {
          "description": "Sets the minimum log level for output (e.g., 'debug', 'info', 'warn').",
          "format": "string",
          "default": "info",
          "name": "MCP_LOG_LEVEL"
        }
      ]
    },
    {
      "registryType": "npm",
      "registryBaseUrl": "https://registry.npmjs.org",
      "identifier": "@cyanheads/ensembl-mcp-server",
      "version": "0.4.3",
      "runtimeHint": "bun",
      "transport": {
        "type": "streamable-http",
        "url": "http://localhost:3010/mcp"
      },
      "packageArguments": [
        {
          "value": "run",
          "type": "positional"
        },
        {
          "value": "start:http",
          "type": "positional"
        }
      ],
      "environmentVariables": [
        {
          "description": "Ensembl REST API base URL. Override to use GRCh37 endpoint or a local mirror.",
          "format": "string",
          "default": "https://rest.ensembl.org",
          "name": "ENSEMBL_BASE_URL"
        },
        {
          "description": "The hostname for the HTTP server.",
          "format": "string",
          "default": "127.0.0.1",
          "name": "MCP_HTTP_HOST"
        },
        {
          "description": "The port to run the HTTP server on.",
          "format": "string",
          "default": "3010",
          "name": "MCP_HTTP_PORT"
        },
        {
          "description": "The endpoint path for the MCP server.",
          "format": "string",
          "default": "/mcp",
          "name": "MCP_HTTP_ENDPOINT_PATH"
        },
        {
          "description": "Authentication mode to use: 'none', 'jwt', or 'oauth'.",
          "format": "string",
          "default": "none",
          "name": "MCP_AUTH_MODE"
        },
        {
          "description": "Sets the minimum log level for output (e.g., 'debug', 'info', 'warn').",
          "format": "string",
          "default": "info",
          "name": "MCP_LOG_LEVEL"
        }
      ]
    }
  ]
}
mcp model-context-protocol streamable-http npm

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